Adult onset stills disease

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AOSD is an inflammatory condition that can cause exhaustion and swelling in your joints, tissues, organs, and lymph nodes. This condition goes through episodes of flare-up and remission: Symptoms can appear and disappear suddenly. They also sometimes never come back. Some people with AOSD may only ever experience one flare-up. Others may have another episode happen again years later, or they may experience multiple episodes in a few months.
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Adult-Onset Still's Disease

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Adult-onset Still’s disease | Symptoms, treatments and new research

Central Avenue No. We report an interesting case of a year-old African-American male who presented with one-month duration of FUO along with skin rash, sore throat, and arthralgia. After extensive workup, potential differential diagnoses were ruled out and the patient was diagnosed with AOSD based on the Yamaguchi criteria. The case history, incidence, pathogenesis, clinical manifestations, differential diagnoses, diagnostic workup, treatment modalities, and prognosis of AOSD are discussed in this case report. AOSD is characterized by the classic triad of persistent high spiking fever, arthralgia, and salmon colored skin rash.
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Adult Onset Still’s Disease: A Review on Diagnostic Workup and Treatment Options

Adult-onset Still's disease AOSD is a form of Still's disease , a rare systemic autoinflammatory disease characterized by the classic triad of fevers , joint pain , and a distinctive salmon-colored bumpy rash. The disease is considered a diagnosis of exclusion. AOSD may present in a similar manner to other inflammatory diseases and to autoimmune diseases , which must be ruled out before making the diagnosis. Prognosis is usually favorable but manifestations of the disease affecting the lungs, heart, or kidneys may occasionally cause severe life-threatening complications.
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First described in , adult-onset Still's disease AOSD is a rare multisystemic disorder considered as a complex multigenic autoinflammatory syndrome. A genetic background would confer susceptibility to the development of autoinflammatory reactions to environmental triggers. Macrophage and neutrophil activation is a hallmark of AOSD which can lead to a reactive hemophagocytic lymphohistiocytosis.
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